PhD Student in Cancer Evolution

The Department of Medicine III (University Hospital of Munich, LMU, Spiekermann lab) and the Core Facility "Mouse Models of Acute Leukemias" (Helmholtz Munich / Jeremias lab) at the DKTK partner site Munich are offering a PhD position as part of the programs »Molecular Diagnostics, Early Detection and Biomarker Development« and »Exploitation of Oncogenic Mechanisms«. Therapy resistance is a major problem in cancer therapy resulting in cancer recurrence and finally therapy failure. This translational project focusses on acquired mechanisms of resistance towards targeted agents in acute leukemias with a focus on Antibody Drug Conjugates (ADC). Multi-omics characterization of in vitro and in vivo models of drug resistance will be used to identify candidates for functional characterization. Moreover, clinical samples will be characterized to validate findings from model systems in human disease. The project will require approximately 50% wet lab und 50% dry lab work.